Get ready for a story so epic it could only unfold in the corridors of the world’s largest museum – the Smithsonian Institution. Museum guard-turned entrepreneur Larry Daly discovers that his favorite exhibits, and some of his best friends, from New York’s Natural History Museum are being shipped off to the archives at the Smithsonian. Larry gets a distress call from the miniature cowboy, Jedediah, reporting that Egyptian ruler Kahmunrah and a trio of heinous henchmen – namely Ivan the Terrible, Napoleon and Al Capone – are plotting to take over the museum, then the world. Speeding to the nation’s capitol, Larry is clearly in over his head. But with some impressive new pals, including the irrepressible Amelia Earhart, along with familiar friends Teddy Roosevelt and Octavius, Larry will stop at nothing to restore the Smithsonian before dawn.

Nintendo DS owners can experience the spirit and humor of the movie in an entertaining side-scrolling adventure. Players use the Touch Screen to manage magic tablet pieces that change Larry's abilities in real-time. Cling to walls, super jump, fly, shrink, charge and stomp your way through the Smithsonian while using Larry's flashlight and key chain to navigate exhibits.