The sequel to Obscure takes place two years after the gruesome events of the first game. The survivors have gone on to college and try to return to their normal lives. After the discovery of a beautiful but strange plant on school campus, events take a turn for the worse. Soon, the college students have to battle for survival once again.

Players of Obscure The Aftermath can choose their character and one AI controlled sidekick. In total there are six playable characters, each with their own unique abilities. These can be switched at various points in the game. Due to the game's co-op feature, friends can join at any time to team up and attempt surviving the game together. There are many available weapons to keep the monsters that hunt you at bay. Light might be the players' biggest ally because you never know what's lurking in the shadows.